She gained the celebrity status playing title role in the T.V serial, Shanti:ek ghar ki kahani. Mandira has also hosted Cricket World Cup with renowned T.V personality Charu Sharma .In the year 1995, she appeared in the Hindi flick Dilwale Dulhania Le Jayenge. The movie starred Shahrukh Khan and Kajol,after that she came back to Television as main villainess 'Mona' in the daily soap 'Kyuki Saas Bhi Kabhi Bahu Thi'.
Mandira has hosted the Television shows like 'Fame Gurukul'. In the game show 'Deal Ya No Deal' she replaced R.Madhavan as an anchor. She also anchored the musical reality show 'Jo Jeeta Wohi Super Star', the show was aired on India's most popular entertainment channel, Star One. In March 2010, she presented the coverage of Indian Premiere League on ITV.Mandira also posed for the cover page of 'Maxim India Magazine'.
